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Upon arriving in the durance of hate, level 3, you receive a new entry in your quest log. It's time to take out Mephisto, the third act's boss monster. Clear out any extraneous monsters before battling Mephisto himself. Be prepared to retreat frequently to replenish health and mana points with potions. Use town portal scrolls as needed to return to town for full rejuvenation and to stock up on additional potions. Mephisto's lightning attacks carry the most damage potential; attempt to arrive with lightning resistance (either through equipment or a paladin's aura) to survive the electrical volley. Mephisto's 100 percent resistance to poison gives him poison damage attack as well. Once you defeat Mephisto, his soulstone is dropped (pick it up), and the infernal gate is opened, leading into the fourth and final act of Diablo II.
Mephisto possesses 100 percent resistance to poison. You'll have more success with cold; Mephisto is only 25 percent resistant to cold attacks. Other resistances include 50 percent resistant to both fire and lightning. Act III, Quest VI Completed Message from Ormus "You have defeated a Prime Evil in combat. Ormus is impressed beyond words. But staying here will not end this conflict. You must enter the Infernal Gate and stop Diablo once and all on his home ground." Act III, Quest VI Rewards Defeating Mephisto opens the infernal gate, letting you proceed into Diablo II's fourth and final act. Also, once you defeat Mephisto, you can pick up Mephisto's soulstone, an important quest item for Act IV. If you forget to pick up the soulstone, don't worry - Deckard Cain will hand it to you in Act IV when it's needed.
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